Renal cell carcinoma with clear cells, smooth muscle stroma, and negative for 3p deletion: a variant of renal angiomyoadenomatous tumour? A case report

Inactivation of the von Hippel–Lindau (V

Inactivation of the von Hippel–Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: Evidence for a VHL-independent pathway in clear cell renal tumourigenesis

✍ Steven C. Clifford; Amanda H. Prowse; Nabeel A. Affara; Charles H. C. M. Buys; E 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 149 KB 👁 2 views

Inactivation of tumour suppressor gene(s) (TSGs) on 3p appears to be a critical event in the pathogenesis of clear cell renal cell carcinoma (CC-RCC). Analysis of loss of heterozygosity (LOH) in sporadic RCC samples has implicated roles for TSGs in three specific regions of 3p in RCC development: (1