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Renal, Biliary and Intestinal Clearance of a Quaternary Ammonium Compound, Emepronium in the Dog

✍ Scribed by Hallén, B. ;Sundwall, A. ;Elwin, C. E. ;Vessman, J.

Book ID
114799580
Publisher
Wiley (Blackwell Publishing)
Year
2009
Weight
971 KB
Volume
44
Category
Article
ISSN
0001-6683

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✍ Robert A. Carr; Franco M. Pasutto; Robert T. Foster 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 531 KB

Biliary clearance (C1, ) of sotalol (STL) enantiomers was assessed in anaesthetized Sprague-Dawley rats (419 f 9 g, mean f SEM, n = 4) following administration of a 10mgkg-' IV dose of the racemate. C1b for S-and R-STL (0~0675f0~0090 and 0.0662 +\_0.0089 mL min-' kg-I, respectively) represented appr