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Renal and endocrine effects of flosulide, after single and repeated administration to healthy volunteers

✍ Scribed by P. Brunel; M. Turri; A. Hornych; T. T. Guyene; J. Ménard; A. Sioufi

Publisher
Springer
Year
1995
Tongue
English
Weight
879 KB
Volume
49
Category
Article
ISSN
0031-6970

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✦ Synopsis

Two double-blind, placebo-controlled, balanced cross-over studies were carried out successively in 8 male normotensive volunteers to investigate the acute and chronic effects of two doses of a novel nonsteroidal anti-inflammatory drug ftosulide (5 mg b.d. and 25 mg b.d.), on the renin-angiotensin-aldosterone system, linking this to changes in the urinary excretion of prostaglandins. Plasma renin and aldosterone were determined on Days 2 and 9, with the subject supine, after 1 h of rest in the sitting position following 1 h of walking, and 3 h after oral intake of 40 mg furosemide, also in the sitting position. Twenty-four hour urine samples were collected on Days 1 and 8 for the measurement of the electrolytes, aldosterone pill and the urinary prostaglandins PGE2, PGF2~, 6-keto-PGF~ and TxB2. Results: After the first day of treatment with 25 mg b.d. flosulide, the increase in body weight was close to significance (0.86 vs -0.08 kg with placebo). A doseand time-dependent decrease in both active and inactive plasma renin were observed, whereas the fall in plasma and urinary aldosterone was statistically significant only after the higher dose of flosulide. These changes in the renin-angiotensin-aldosterone system were observed in the absence of oedema.

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