## Abstract Olfactory ensheathing cells (OECs), although having a separate developmental origin to Schwann cells, are able to generate myelin sheaths following transplantation into areas of CNS demyelination that are remarkably similar to those made by Schwann cells. The transcriptional control of
Remyelination by transplanted olfactory ensheathing cells
β Scribed by Franklin, Robin J.M.
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 582 KB
- Volume
- 271B
- Category
- Article
- ISSN
- 0003-276X
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Human olfactory ensheathing cells (OECs) were prepared from adult human olfactory nerves, which were removed during surgery for frontal base tumors, and were transplanted into the demyelinated spinal cord of immunosuppressed adult rats. Extensive remyelination was observed in the lesion site: In sit
## Abstract In a previous study we found that olfactory ensheathing cells transplanted into complete retrobulbar transections of the rat optic nerve mediated regeneration of severed retinal ganglion cell axons through the graft region. Although the regenerating axons were ensheathed by the transpla
## Abstract **BACKGROUND:** Transplantation of olfactory ensheathing cells (OEC) to regenerate damaged spinal tracts and induce functional recovery following spinal cord injury (SCI) has been trialed in the clinic. Evidence suggests that the regenerative capacity of OEC is induced by soluble, secre