✦ LIBER ✦

Removal of thallium by deferasirox in rats as biological model

✍ Scribed by Amir Sh. Saljooghi; S. Jamiladin Fatemi

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 211 KB
Volume: 31
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.1573

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The present research aimed to characterize the potential efficiency of deferasirox in removing thallium after its administration for 30 days following two dose levels of 20 and 160 μm of thallium (III) chloride to male Wistar rats every day. After thallium administration some abnormal clinical signs such as red staining around the eyes, greenish mottling on the liver, weakness, loss of hair and weight, were observed in animals. Deferasirox was given orally to different groups of rats for a period of one week immediately after thallium administration. After chelation therapy, animals were killed by exsanguination from the abdominal aorta, and then thallium and iron concentrations in various tissues were determined by standard addition method. The chelation therapy results showed that deferasirox was able to remove thallium ions from the body and clinical symptoms were also reduced. Copyright © 2010 John Wiley & Sons, Ltd.

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