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Removal of O6-methylguanine from DNA of normal and xeroderma pigmentosum-derived lymphoblastoid lines

✍ Scribed by Sklar, Robert; Strauss, Bernard

Book ID
109721877
Publisher
Nature Publishing Group
Year
1981
Tongue
English
Weight
445 KB
Volume
289
Category
Article
ISSN
0028-0836

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## Abstract The DNA repair protein __O__^6^‐methylguanine‐DNA methyltransferase (MGMT) has been implicated in resistance of human brain tumors to alkylating agents. We observed that 14 human medulloblastoma‐ and gliomaderived cell lines differ in sensitivity to the methylating agent __N__‐methyl‐__