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Remote stereocontrol in acyclic systems. Hydride addition to 1,5- and 1,6-hydroxy ketones mediated by metal chelation

โœ Scribed by Edward C. Lawson; Han-Cheng Zhang; Bruce E. Maryanoff


Book ID
108387299
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
253 KB
Volume
40
Category
Article
ISSN
0040-4039

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Swnmmy: A variety of educing agents was explored to &act stereoselective nduction of acyclic Shydroxy ketone 3a; R-Alpine-Hydride pmvided high aM sterwaelectivity (unci:syn = 7: 1). Reduction of 3b in cl-&cl2 with R-Alpine-Hydri& or Zn(BH& affo&d impressive anti smleetivity: 1O:l and 13:1, respectiv