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Remote, semiautomated production of 6-[18F]fluoro-l-dopa for human studies with PET

✍ Scribed by Andre Luxen; Milton Perlmutter; Gerald T. Bida; Glenn Van Moffaert; Joseph S. Cook; Nagichettiar Satyamurthy; Michael E. Phelps; Jorge R. Barrio

Publisher: Elsevier Science
Year: 1990
Weight: 664 KB
Volume: 41
Category: Article
ISSN: 0883-2889
DOI: 10.1016/0883-2889(90)90191-i

No coin nor oath required. For personal study only.

✦ Synopsis

Regioselective radiofluorodemercuration of the 6-mercurio derivative 5 with [18F]acetylhypofluorite afforded, after acidic hydrolysis, 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine (6-FD, 1) with a radiochemical yield of 11% (decay corrected and based on the total amount of [18F]F2 recovered from the target). 6-FD was obtained with a chemical and radiochemical purity of greater than 99% and with a level of mercury in the final preparation of less than 20 ppb. Utilization of a remote, semiautomated production system, resulted in the preparation of a sterile, pyrogen-free product suitable for human injection after a synthesis time of 50 min.

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