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Remodelling of Cardiac Extracellular Matrix duringβ-adrenergic Stimulation: Upregulation of SPARC in the Myocardium of Adult Rats

✍ Scribed by Serge Masson; Beatrice Arosio; Giuseppina Luvarà; Nicoletta Gagliano; Fabio Fiordaliso; Daniela Santambrogio; Carlo Vergani; Roberto Latini; Giorgio Annoni

Book ID
115632670
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
761 KB
Volume
30
Category
Article
ISSN
0022-2828

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## Abstract We have shown that the stimulation of β‐adrenergic receptors (β‐AR) increases apoptosis in adult rat ventricular myocytes (ARVMs). Integrins, a family of αβ‐heterodimeric cell surface receptors, are postulated to play a role in ventricular remodeling. Here, we show that norepinephrine (