Reconstructing Potentials of Mean Force
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Justin R Gullingsrud; Rosemary Braun; Klaus Schulten
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Article
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1999
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Elsevier Science
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English
โ 158 KB
Atomic force microscopy (AFM) experiments and steered molecular dynamics (SMD) simulations have revealed much about the dynamics of protein-ligand binding and unbinding, as well as the stretching and unfolding of proteins. Both techniques induce ligand unbinding or protein unfolding by applying exte