REM sleep eye movement activity and CSF concentrations of 5-hydroxyindoleacetic acid in psychiatric patients

Effects of single doses of vigabatrin on

Effects of single doses of vigabatrin on CSF concentrations of GABA, homocarnosine, homovanillic acid and 5-hydroxyindoleacetic acid in patients with complex partial epilepsy

✍ Elinor Ben Menachem; Lennart I. Persson; Paul J. Schechter; Klaus D. Haegele; No 📂 Article 📅 1988 🏛 Elsevier Science 🌐 English ⚖ 615 KB

Vigabatrin, as a single oral dose of 50 mg/kg, was administered to 11 patients with drug-refractory complex partial epilepsy. Serial lumbar punctures were performed prior to and 5 times within the first week following treatment. Cerebrospinal fluid (CSF) concentrations of total GABA, free GABA, homo