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Relevance of genetic polymorphism in drug metabolism in the development of new drugs

โœ Scribed by L. P. Balant; U. Gundert-Remy; A. R. Boobis; Ch. Bahr


Publisher
Springer
Year
1989
Tongue
English
Weight
483 KB
Volume
36
Category
Article
ISSN
0031-6970

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## Abstract Metabolism by the host organism is one of the most important determinants of the pharmacokinetic profile of a drug. High metabolic lability usually leads to poor bioavailability and high clearance. Formation of active or toxic metabolites will have an impact on the pharmacological and t