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Relevance of cytotoxic alloreactivity under different immunosuppressive regimens in clinical islet cell transplantation

โœ Scribed by D. L. Roelen; V. A. L. Huurman; R. Hilbrands; P. Gillard; G. Duinkerken; P. W. M. Van Der Meer-Prins; M. F. J. Versteeg-van der Voort Maarschalk; C. Mathieu; B. Keymeulen; D. G. Pipeleers; B. O. Roep; F. H. J. Claas


Book ID
108700938
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
260 KB
Volume
156
Category
Article
ISSN
0009-9104

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## Background: Regulatory T-cells (Treg) are natural suppressors of autoimmunity. Previous studies indicate that immunosuppressive drugs, especially calcineurin-inhibitors, may interfere with Treg homeostasis. Inflammatory bowel disease (IBD) can relapse or develop de novo after liver transplantati