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Relevance of animal models for percutaneous absorption

โœ Scribed by Wester, Ronald C.; Noonan, Patrick K.


Book ID
123570172
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
777 KB
Volume
7
Category
Article
ISSN
0378-5173

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The percutaneous absorption of 1,3,5-trinitrobenzene (TNB) was studied in viable skin from hairless guinea pigs (HGP), Fischer 344 rats and humans. Skin was dermatomed and assembled in flow-through diffusion cells followed by TNB application in either an acetone or a water vehicle. Skin absorption w