Relevance of a scoring system including CD11c expression in the identification of splenic diffuse red pulp small B-cell lymphoma (SRPL)
✍ Scribed by L. Baseggio; A. Traverse-Glehen; E. Callet-Bauchu; D. Morel; J.P. Magaud; F. Berger; G. Salles; P. Felman
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 199 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0278-0232
- DOI
- 10.1002/hon.957
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
‘Splenic red pulp lymphoma with numerous basophilic villous lymphocytes’ (SRPL), recently described, is characterized by clinical, morphologic, immunologic, cytogenetic and molecular features distinct from SMZL/SLVL and HCL. In particular, the intensity of CD11c staining (expressed as fluorescence intensity ‐RFI‐) in SRPL is significantly different from the RFI in SMZL/SLVL and HCL. Moreover the use of a scoring system based on the expression of CD11c, CD22, CD76, CD38 and CD27 appears to improve the differential diagnosis between SRPL and SMZL/SLVL and emphasizes that SRPL is an entity closed to but distinct from SMZL/SLVL. Copyright © 2010 John Wiley & Sons, Ltd.