Release of vitamin B12 from poly(N-vinyl-2-pyrrolidone)-crosslinked polyacrylamide hydrogels: A kinetic study
✍ Scribed by R. Dengre; M. Bajpai; S. K. Bajpai
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 173 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0021-8995
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✦ Synopsis
Hydrogels, composed of poly(N-vinyl-2-pyrrolidone) and crosslinked polyacrylamide, were synthesized and the release of vitamin B 12 from these hydrogels was studied as a function of the degree of crosslinking and pH of the external swelling media. The three drug-loaded hydrogel samples synthesized with different crosslinking ratios of 0.3, 0.7, and 1.2 (in mol %) follow different drug-release mechanisms, that is, chain relaxation with zero-order, non-Fickian and Fickian, or diffusion-controlled mechanisms. To establish a correlation between their swelling behavior and drugrelease mechanism, the former was studied by the weight-gain method and, at the same time, the concentration of the drug released was studied colorimetrically. Various swelling parameters such as the swelling exponent n, gel-characteristic constant k, penetration velocity v, and diffusion coefficient D were evaluated to reflect the quantitative aspect of the swelling behavior of these hydrogels. Finally, the drug-release behavior of the hydrogels was explained by proposing the swelling-dependent mechanism.