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Release of the predicted calcitonin gene-related peptide from cultured rat trigeminal ganglion cells

✍ Scribed by Mason, R. Tom; Peterfreund, Robert A.; Sawchenko, Paul E.; Corrigan, Anne Z.; Rivier, Jean E.; Vale, Wylie W.


Book ID
109735122
Publisher
Nature Publishing Group
Year
1984
Tongue
English
Weight
366 KB
Volume
308
Category
Article
ISSN
0028-0836

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Addition of calcitonin gene-related peptide (CGRP) to rat glomerular mesangial cells in culture resulted in an increase in cyclic adenosine monophosphate (cAMP) accumulation in a concentration-dependent fashion with an EC50 of approximately 3 nM. Inclusion of CGRP8-37, a CGRP1 selective antagonist s