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Release of the p53-Induced Repression on Thymidine Kinase Promoter by Single p53-Binding Sequence

✍ Scribed by J.N. Yuan; B.H. Liu; H. Lee; Y.T. Shaw; S.T. Chiou; W.C. Chang; M.D. Lai

Book ID
115572656
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
373 KB
Volume
191
Category
Article
ISSN
0006-291X

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## Abstract Herein, we show that both exogenously transfected and endogenously activated p53 repress promoter activity and expression of PDGFRB. p53 binds the proximal promoter containing the CCAAT motif as examined by EMSA and chromatin immunoprecipitation. However, gradual induction of p53 in tet