Release of platelets into the circulation induced by gamma globulin treatment in a case of idiopathic thrombocytopenic purpura

✍ Scribed by Schmidt, K. G. ;Rasmussen, J. W. ;Diederichsen, H. ;Ulrich, M.

• Publisher: Springer-Verlag
• Year: 1984
• Weight: 379 KB
• Volume: 48
• Category: Article
• ISSN: 1432-0584
• DOI: 10.1007/bf00320714

✦ Synopsis

The kinetics and distribution in vivo of 111In-labelled platelets prior to and during intravenous high-dose gamma globulin therapy in a 3-months-old child with idiopathic thrombocytopenic purpura were evaluated. Concomitantly with a prompt increase in platelet concentration we found evidence for release of platelets into the circulation, presumably to a large extent originating from the spleen and liver. Our results support the concept that, in response to high-dose gamma globulin therapy, platelets are not only forced to remain in but are also released into the circulation, presumably as a result of mobilization of platelets adhering to cells of the monocyte-macrophage system.