## Abstract Although originally known as a plasma serine protease involved in clot dissolution, tPA and its primary inhibitor, PAIโ1, play crucial roles in synaptic reorganization and plasticity in the central nervous system. In contrast to the wide array of work conducted in neural cells, relative
โฆ LIBER โฆ
Release of plasminogen activator inhibitor-1 from human astrocytes is regulated by intracellular ceramide
โ Scribed by Masahiko Kimura; Shinji Soeda; Masatoshi Oda; Takashi Ochiai; Taro Kihara; Nobufumi Ono; Hiroshi Shimeno
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 202 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0360-4012
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## Abstract We have shown that the bacterial iron chelator, deferoxamine (DFO), triggers inflammatory signals including the production of CXC chemokine ILโ8, in human intestinal epithelial cells (IECs) by activating the ERK1/2 and p38 kinase pathways. In this study we investigated the mechanisms in