Release of norepinephrine and dopamine from brain vesicular preparations: Effects of calcium antagonists
β Scribed by Richard P. Ebstein; John W. Daly
- Publisher
- Springer
- Year
- 1982
- Tongue
- English
- Weight
- 466 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0272-4340
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Recent studies indicate that the extraneuronal concentrations of different neurotransmitters increase in the brain following anoxia (Zetterstr6m et al. 1982;Benveniste et al. 1984;Globus et al. 1988;Slivka et al. 1988). Accordingly, a massive release of dopamine (DA) has recently been measured by mi
## Abstract Hydroxylamine (0.01β30 mM), a nitric oxide (NO) generator, produced a concentrationβdependent release of [^3^H]dopamine ([^3^H]DA) from rat striatal slices. Hemoglobin (10 ΞΌM), a NO scavenger, reduced basal [^3^H]DA release and blocked hydroxylamine (100 ΞΌM)βstimulated [^3^H]DA efflux.