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Release of cytochrome c from mitochondria precedes Bax translocation/activation in Triton X-100-induced apoptosis

✍ Scribed by Hirofumi Sawai; Naochika Domae

Book ID
104040485
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
591 KB
Volume
32
Category
Article
ISSN
0145-2126

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✦ Synopsis

The precise mechanisms by which sublytic concentrations of detergents induce apoptosis remain unclear. Recent studies reported the ability of nonionic detergents such as Triton X-100 to induce conformational change of Bax to the active form in vitro. Here we investigated whether activation of Bax might play a role in Triton X-100-induced apoptosis in cells. Although Bax translocation/activation was inhibited by caspase inhibitors, cytochrome c release from mitochondria was not affected in Triton X-100-induced apoptosis in U-937 cells. These results demonstrate that translocation/activation of Bax occurs downstream of cytochrome c release and caspase activation in Triton X-100-induced apoptosis.

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