Release of corrosion products by F-75 cobalt base alloy in the rat. I: Acute serum elevations
✍ Scribed by Koegel, A. ;Black, J.
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 547 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0021-9304
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✦ Synopsis
The release of corrosion products by implants has become a matter of concern. Using a microsphere model, the release of chromium, cobalt, and nickel, secondary to implantation of various surface area exposures of F-75, a cast cobalt-chromium alloy, was studied over a 30 day period in the rat. Dose related elevations were observed in the serum concentration of chromium and cobalt but not of nickel, with the maxima being achieved at 3 days after metal implantation followed by declines in concentration. The chromium elevation, approximately twelvefold for a surface area to body weight (SNBW) ratio of 3 0 0 ~ is similar to that previously reported in patients receiving total hip replacement arthoplasties. However, the cobalt elevation, twentyfold for a SA/BW ratio of 300 x , has not been previously observed.
These serum concentration changes are as yet unexplained, but are probably not due to fibrous capsule maturation or alloy repassivation.