𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Release of Chlorambucil from Poly(N-isopropylacrylamide) Hydrogels with β-Cyclodextrin Moieties

✍ Scribed by Yu-Yang Liu; Xiao-Dong Fan; Hui Hu; Zhong-Hua Tang

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
126 KB
Volume
4
Category
Article
ISSN
1616-5187

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Summary: The present work is focused on investigating the behavior of controlled drug release poly(N‐isopropylacrylamide) (PNIPA) hydrogels in the presence of β‐cyclodextrin (β‐CD). For this purpose, three types of NIPA hydrogels with β‐CD moieties were synthesized with different architectures according to our previous studies. An anti‐cancer drug (chlorambucil, CLB), which can form an inclusion complex with β‐CD, was selected for loading and in vitro release studies. The drug was loaded into hydrogels via a swelling method. DSC was used to study the interactions between the CLB molecules and the polymers. The results indicate that the CLB‐polymer interactions are at the molecular level. Loading CLB into these polymers can result in an evident decrease in the glass transition temperature (T~g~), and the variation of T~g~ (Δ__T__~g~) depends on the structures of the polymers and their β‐CD content. The controlled release experiments show that the presence of β‐CD can markedly enhance CLB release from shrunken PNIPA hydrogels and increase the ratio of CLB released in total drug loading content.

Release profile of CLB from hydrogels 1a‐c and 4 at pH 1.4 and 7.4, at 37 °C.

magnified imageRelease profile of CLB from hydrogels 1a‐c and 4 at pH 1.4 and 7.4, at 37 °C.

📜 SIMILAR VOLUMES

Controlled release of aminophylline from
Controlled release of aminophylline from poly (N-isopropylacrylamide-co-itaconic acid) hydrogels
✍ Issa Katime; Nora Valderruten; José R Quintana 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 121 KB

## Abstract __N__‐Isopropylacrylamide (NIPA) has been copolymerized with itaconic acid (IA) in the presence of __N,N__‐methylenebisacrylamide (BIS) as crosslinker. The swelling capacity and the release rate of aminophylline at 37 °C are reported. Maximum equilibrium swelling increases as the itacon

Supramolecular Thermoresponsive Hyperbra
Supramolecular Thermoresponsive Hyperbranched Polymers Constructed from Poly(N-Isopropylacrylamide) Containing One Adamantyl and Two β-Cyclodextrin Terminal Moieties
✍ Zhishen Ge; Hao Liu; Yanfeng Zhang; Shiyong Liu 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 325 KB

## Abstract Poly(__N__‐isopropylacrylamide) (PNIPAM) oligomer containing one adamantyl (AD) and two β‐cyclodextrin (β‐CD) moieties at the chain terminals, __AD__‐PNIPAM‐(β‐__CD__)~2~, was synthesized by atom transfer radical polymerization (ATRP) and successive click reactions. In aqueous solution,

Preparation and Characterization of Nove
Preparation and Characterization of Novel Temperature Sensitive Poly(N-isopropylacrylamide-co-acryloyl beta-cyclodextrin) Hydrogels with Fast Shrinking Kinetics
✍ Jian-Tao Zhang; Shi-Wen Huang; Ren-Xi Zhuo 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 184 KB

## Abstract **Summary:** Novel temperature sensitive poly(__N__‐isopropylacrylamide‐__co__‐acryloyl beta‐cyclodextrin) (P(NIPA‐__co__‐A‐CD)) hydrogels with fast shrinking rates were prepared by radical polymerization of NIPA, A‐CD and crosslinker in a mixture of water/1,4‐dioxane as solvent. Becaus