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Release and clinical significance of soluble CD83 in chronic lymphocytic leukemia

โœ Scribed by B.D. Hock; L.J. Fernyhough; S.M. Gough; A. Steinkasserer; A.G. Cox; J.L. McKenzie

Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
488 KB
Volume
33
Category
Article
ISSN
0145-2126

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โœฆ Synopsis

Soluble CD83 (sCD83), a potent immunosuppressive agent, circulates at elevated levels in some chronic lymphocytic leukemia (CLL) patients. We report that CLL patients with elevated plasma sCD83 levels had significantly shorter (P=0.038) treatment free survival. Culture of CLL cells with solid phase CD83 mAb+IL-4 significantly increases sCD83 release (23-117-fold, P=0.013) and ligation of normal donor PBMC with solid phase CD83 mAb alone induces similar significant increases in sCD83 release (P=0.003). RT-PCR analysis detected the presence of a transcript for sCD83 in 2/3 CLL samples. These results suggest sCD83 release may play a regulatory role in CLL progression.

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## Abstract ## BACKGROUND Patients with chronic lymphocytic leukemia (CLL) that transforms to Richter syndrome (RS) frequently show atypical lymphocytes in bone marrow; however, a diagnosis of RS requires confirmation of the presence of sheets of large cells in bone marrow or lymph nodes. ## METH