Relaxivity enhancement of low molecular weight nitroxide stable free radicals: Importance of structure and medium
✍ Scribed by Patrick Vallet; Yves van Haverbeke; Pierre Antoine Bonnet; Guy Subra; Jean-Pierre Chapat; Professor Robert N. Muller
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 473 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
The longitudinal relaxivities of seven water‐soluble nitroxide derivatives ot low‐molecular weight have been measured at 5°C and 37°C in water and in serum between 0.01 and 200 MHz. The nuclear magnetic relaxation dispersion (NMRD) profiles show a clear relationship between the relaxivity observed in serum and the relative balance of the hydrophobichydrophilic character of the paramagnetic molecules. From the data analysis, contributions arising from a population of nitroxides characterized by reduced mobility can be extracted. The values of the correlation times are consistent with a system involving nitroxides adsorbed at the surface of albumin and magnetically interacting with the protons of hydrogen bonded water molecules.