Relaxin favors the development of activated human T cells into Th1-like effectors

Activated, but not resting human Th2 cel

Activated, but not resting human Th2 cells, in contrast to Th1 and T regulatory cells, produce soluble ST2 and express low levels of ST2L at the cell surface

✍ Sandrine Lécart; Nathalie Lecointe; Arun Subramaniam; Sefik Alkan; Donghui Ni; R 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 337 KB 👁 1 views

The T1/ST2 gene encodes, as a result of differential splicing, a cell surface protein (transmembrane form of T1/ST2, ST2L) and a soluble, secreted, protein (ST2). Here, we show that transcripts for both ST2L and ST2 are present in activated human Th2 clones, but not in Th1 and T regulatory clones. T