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Relaxation spectra of two-step mechanisms as measured by the nadh-binding to glutamate dehydrogenase

✍ Scribed by Manfred Kempfle


Publisher
Springer
Year
1977
Tongue
English
Weight
638 KB
Volume
39
Category
Article
ISSN
1522-9602

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✦ Synopsis


Temperature-jump relaxation experiments performed with glutamate dehydrogenase and the reduced coenzyme nicotinamide adenosine dinueleotide show two clearly separated relaxation times. Three of the simplest and most plausible mechanisms attributable to two relaxation times are treated here theoretically and the concentration dependence of the relaxation times is determined in each case with different experimental conditions. This makes it possible to distinguish between the mechanisms and also to determine the rate constants of the different reaction steps.