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Relaxation and crystallization of amorphous carbamazepine studied by terahertz pulsed spectroscopy

✍ Scribed by J. Axel Zeitler; Philip F. Taday; Michael Pepper; Thomas Rades

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 483 KB
Volume: 96
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.20908

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✦ Synopsis

At the example of carbamazepine the crystallization of a small organic molecule from its amorphous phase was studied using in situ variable temperature terahertz pulsed spectroscopy (TPS). Even though terahertz spectra of disordered materials in the glassy state exhibit no distinct spectral features we demonstrate subtle changes in the spectra with increasing temperature and discuss the findings in respect to the density of vibrational states. The crystallization leads to distinct spectral features allowing the crystallization and subsequent polymorphic phase transition at higher temperatures to be studied in detail. It is possible to study both relaxation and crystallization processes by variable temperature TPS.

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