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Relaxant effect of oxime derivatives in isolated rat aorta: role of nitric oxide (NO) formation in smooth muscle

✍ Scribed by Karel Chalupsky; Irina Lobysheva; Françoise Nepveu; Irina Gadea; Petra Beranova; Gustav Entlicher; Jean-Claude Stoclet; Bernard Muller

Book ID
118426413
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
405 KB
Volume
67
Category
Article
ISSN
0006-2952

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The relaxing effect of adrenomedullin (AM) and that associated with nitric oxide (NO) were investigated in rat isolated aorta. The relaxing effect produced by AM was almost completely inhibited by the removal of endothelium and by treatment with the NOS inhibitor fl-nitro-L-arginine methyester (L-NA