✦ LIBER ✦

Relative preservation of thalamic centromedian nucleus in parkinsonian patients with dystonia

✍ Scribed by Linda Truong; Daniel Brooks; Fabricio Amaral; Jasmine M. Henderson; Glenda M. Halliday

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 398 KB
Volume: 24
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.22747

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

To determine whether variable thalamic degeneration in Parkinson's disease (PD) contributes to less drug responsive clinical features. Formalin‐fixed thalami from longitudinally followed patients with PD and early dystonia (N = 6), early falls (N = 5) or no dystonia or falls (N = 6) and age‐matched controls without neuropathology (N = 10) were serially sectioned, stained, and analyzed. Neurons in the centromedian parafascicular (CM‐Pf) nucleus were quantified using the optical disector method and analysis of variance with post hoc testing used to determine variability in neurodegeneration between groups. Patients with PD were confirmed to have significant neurodegeneration in the CM‐Pf complex, with no difference in the degree of neurodegeneration between patients with PD with early falls compared with patients with no history of falls or dystonia. In contrast, patients with PD with early dystonia had significantly less neurodegeneration of the CM but not the Pf than patients without this feature. Preservation of the CM in patients with PD with early dystonia would result in a relative increase in CM activity through the direct basal ganglia pathway and increased primary motor cortex activity. Overall this data provides evidence for pathway‐specific neurodegeneration as an underlying feature of the clinical variability observed in patients with PD. © 2009 Movement Disorder Society

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