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Relative Importance of Intestinal and Hepatic Glucuronidation—Impact on the Prediction of Drug Clearance

✍ Scribed by Helen E. Cubitt; J. Brian Houston; Aleksandra Galetin


Book ID
106493658
Publisher
Springer US
Year
2009
Tongue
English
Weight
265 KB
Volume
26
Category
Article
ISSN
0724-8741

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✍ Leonid M. Berezhkovskiy; S. Cyrus Khojasteh; Jason S. Halladay; Cornelis E.C.A. 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 117 KB

It was suggested that in vivo hepatic clearance, CL h , may be predicted rather accurately with the in vitro values of intrinsic clearance, CL int , obtained using the microsomal incubation mix containing diluted plasma, and consequently calculated by the well-stirred model equation. Conceivably the