One can obtain population-based estimates of the penetrance of a measurable mutation from cohort studies, from population-based case-control studies, and from genotyped-proband designs (GPD). In a GPD, we assume that representative individuals (probands) agree to be genotyped, and one then obtains i
Relative Efficiency of the Case-Control to the Cohort Design in Epidemiology
โ Scribed by K. Daniels; Professor Emeritus R. McHugh
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 447 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0323-3847
No coin nor oath required. For personal study only.
โฆ Synopsis
In deriving the efficiency of the stratified to the simple random sample design in survey research, the criticul link between the designs is the population analysis of variance. Analogously, the efficiency of the case-control to the cohort design in epidemiologic research can be derived using Bnyes' theorem as the essential connection between the designs. Prior information on the odds of the disease is also required. A numerical example using data from Fleiss' t e x t is used to illiistmte the result.
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