Relative configuration of the diacid sidechain of isoharringtonine

✍ Scribed by Touran Ipaktchi; Steven M. Weinreb

• Publisher: Elsevier Science
• Year: 1973
• Tongue: French
• Weight: 156 KB
• Volume: 14
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)87066-0

✦ Synopsis

There has been considerable interest in the Ceuhalotaxus alkaloids recently due both to the unusual structure of the parent alkaloid cephalotsxine (7.) and to the promising antileukemia activity of the harringtonines, which are esters of cephalotaxine with severalacyclic dicarboxylic acids. 1-4