✦ LIBER ✦

Relative bioavailability estimation of carbamazepine crystal forms using an artificial stomach-duodenum model

✍ Scribed by Stephen R. Carino; David C. Sperry; Michael Hawley

Book ID: 102394424
Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 334 KB
Volume: 95
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.20495

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✦ Synopsis

The in vitro dissolution of carbamazepine (CBZ) was investigated using an automated artificial stomach-duodenum (ASD) model. Successful simulation of the dog physiology in the fasted state showed that the rank order of the ASD estimated bioavailabilities is as follows: Form III > Form I > dihydrate. This result is in excellent agreement with those found in literature. Additional simulations comparing different gastric transit times during fasted and fed states are also discussed.

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