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Relationships between tumor responsiveness, vincristine pharmacokinetics and arrest of mitosis in human tumor xenografts

✍ Scribed by Julie K. Horton; Peter J. Houghton; Janet A. Houghton

Book ID
115780125
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
731 KB
Volume
37
Category
Article
ISSN
0006-2952

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Relationships among tumor responsiveness
Relationships among tumor responsiveness, cell sensitivity, doxorubicin cellular pharmacokinetics and drug-induced DNA alterations in two human small-cell lung cancer xenografts
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In an attempt to understand the underlying cellular/ biochemical factors of sensitivityhesistance in human smallcell lung cancer (SCLC), 2 SCLC tumor lines were compared with respect to tumor responsiveness to drug treatment, cell sensitivity, cellular doxorubicin accumulation, and DNA topoisomerase