Relationships between superoxide levels and delayed calcium deregulation in cultured cerebellar granule cells exposed continuously to glutamate

Calcium influx via L-type voltage-gated

Calcium influx via L-type voltage-gated channels mediates the delayed, elevated increases in steady-state c-fos mRNA levels in cerebellar granule cells exposed to excitotoxic levels of glutamate

✍ Roger Griffiths; Lyndsay Ritchie; Kate Lidwell; Angus Grieve; Craig S. Malcolm; 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 442 KB 👁 1 views

The altered kinetics of steady-state c-fos mRNA production in cultured cerebellar granule cells under excitotoxic conditions was investigated in neurons subjected to depolarising stimuli, namely, high KCl and L-glutamate (Glu), in which Ca 2؉ influx occurs by differing routes. Increases in intracell