Relationship of tumor grade to other pathologic features and to treatment outcome of patients with early stage breast carcinoma treated with breast-conserving therapy

✍ Scribed by Asa J. Nixon; Stuart J. Schnitt; Rebecca Gelman; Irene Gage; Bruce Bornstein; Stella Hetelekidis; Abram Recht; Barbara Silver; Jay R. Harris; James L. Connolly

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 630 KB
• Volume: 78
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/(sici)1097-0142(19961001)78:7<1426::aid-cncr8>3.0.co;2-i

✦ Synopsis

BACKGROUND.

Although histologic grade has previously been described as a predictor of distant failure, it xs uncertain whether histologic grade should be used to decide which patients should undergo axillary lymph node dissection and whether grade should be considered as a selection factor for breast-conserving therapy.

METHODS.

The authors retrospectively analyzed data from 1081 patients with h e rican Joint Committee on Cancer Stage I or I1 infiltrating ductal carcinoma treated with breast-conserving therapy at the Joint Center for Radiation Therapy between 1970 and 1986. All patients had pathology slides reviewed by one of two study pathologists. Using the Elston modification of the Bloom-Richardson grading system, patients were divided by histologic grade into 3 groups (219 with Grade I, 482 with Grade 11, and 380 with Grade 111). The median follow-up time for 716 survivors was 134 months. The incidence of various pathologic features was examined with respect to histologic grade. In addition, the 10-year crude rates of failure (by first site) were examined as they related to grade. A polychotomous logistic regression model was used to determine the effect of grade on local and distant failure.