Relationship of polymorphisms located in tumor necrosis factor region and HLA loci among Croatians
β Scribed by Katarina Stingl; Zorana Grubic; Helena Car; Renata Zunec
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 196 KB
- Volume
- 21
- Category
- Article
- ISSN
- 1042-0533
No coin nor oath required. For personal study only.
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Objective. To investigate 1) tumor necrosis Factor (TNF) microsatellite allele frequencies in rheumatoid arthritis (RA), and 2) associations between TNF microsatellites and RA-associated HLA specificities in order to build up extended HLA haplotypes. Methods. Eighty-five Caucasoid patients with RA
## Objective Antiβtumor necrosis factor (anti-TNF) agents are successful therapies in rheumatoid arthritis (RA); however, inadequate response occurs in 30β40% of patients treated. Knowledge of the genetic factors that influence response may facilitate personalized therapy. The purpose of this study