Relationship of P53 mutations in laryngeal cancer and tobacco smoking
โ Scribed by Manuel C.Pais Clemente; Laudelina Pais Clemente; Vitor Cardoso; Raquel Seruca; Conceicao Souto-Moura; Paulo Abreu-Dias
- Book ID
- 116809976
- Publisher
- SAGE Publications
- Year
- 2004
- Tongue
- English
- Weight
- 42 KB
- Volume
- 131
- Category
- Article
- ISSN
- 0194-5998
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๐ SIMILAR VOLUMES
Validated markers are needed to identify operable lung cancer patients with poor prognosis. About one-half of nonsmall-cell lung cancers (NSCLCs) carry a mutation in the p53 tumor-suppressor gene. We examined 101 NSCLC patients for surgical stage, completeness of resection, tobacco smoking, asbestos
Mutations of the p53 tumor suppressor gene are frequent in lung cancers. It is suggested that p53 mutations are associated with smoking-induced lung carcinogenesis. We examined p53 mutations in 53 lung cancers by analyzing reverse transcription-polymerase chain reaction-single strand conformation po