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Relationship of high-density lipoprotein subfractions and cholesteryl ester transfer protein in plasma to carotid artery wall thickness

✍ Scribed by B. Föger; G. Luef; A. Ritsch; C. Schmidauer; A. Doblinger; M. Lechleitner; F. Aichner; J. R. Patsch

Publisher
Springer
Year
1995
Tongue
English
Weight
410 KB
Volume
73
Category
Article
ISSN
0946-2716

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✦ Synopsis

High plasma concentrations of high-density lipoprotein (HDL) cholesterol are a powerful indicator of low vascular risk. By decreasing HDL cholesterol, cholesteryl ester transfer protein (CETP) could perhaps constitute an atherogenic protein. We measured HDL cholesterol and HDL subfractions and quantified CETP mass in fasting plasma in 21 asymptomatic probands, and related these variables to the mean intima media thickness of the extracranial carotid arteries. HDL 2 cholesterol, the less dense HDL subfraction, was inversely related to carotid wall thickness (r=-0.378; P<0.05), and CETP was directly related to carotid wall thickness (r=0.436; P<0.05). In plasma CETP is associated mostly with the HDL 3 subfraction. We therefore calculated from our measurements the relative CETP content of HDL 3, i.e., CETP/HDL 3 cholesterol. This ratio was correlated with carotid wall thickness stronger than any other variable measured (r=0.718, P<0.001). We conclude that variation in HDL subfractions and CETP may be more closely associated with carotid intima media thickness than the accepted strong risk factor of HDL cholesterol.

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