The single-active-X hypothesis states that in any mammal with more than one X chromosome per cell, only one X is active in each cell. The hypothesis furrher states that X-chromosome differentiation occurs randomly in each cell early in development and subsequently is stable. The phenotype of a mamma
Relationship of genotype and degree of chimerism in coat color to sex ratios and gametogenesis in chimeric mice
β Scribed by Mullen, R. J. ;Whitten, W. K.
- Publisher
- John Wiley and Sons
- Year
- 1971
- Tongue
- English
- Weight
- 862 KB
- Volume
- 178
- Category
- Article
- ISSN
- 0022-104X
No coin nor oath required. For personal study only.
β¦ Synopsis
Genotype and the degree of chimerism expressed in the coat color of chimeric (allophenic) mice were found to be related to the frequency of multicolored chimeras, the sex ratio, and the production of gametes. The sex ratios of 310 chimeric mice of various combinations of genotypes were studied. The male:female ratios varied from 1:l to ratios approaching 3 : l . Multicolored chimeras in which one genotype predominated ("unbalanced" genotypes) had normal sex ratios of 1 : l (19dd , 2 1 9 0 ) suggesting that sex was determined by the predominating component. Multicolored chimeras in which neither component predominated ("balanced' genotypes) had sex ratios approaching 3:l (70 1 Included as part of a thesis by R. J. M. submitted as a partial requirement for the degree of Doctor of Philosophy at the University of New Hampshire.
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