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Relationship between white matter changes and cognition in healthy elders

✍ Scribed by Miho Ota; Kiyotaka Nemoto; Noriko Sato; Fumio Yamashita; Takashi Asada

Book ID
102230278
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
127 KB
Volume
24
Category
Article
ISSN
0885-6230

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✦ Synopsis

Abstract

Objectives

Cerebral WMHs on T2‐weighted magnetic resonance imaging (MRI) are common incidental findings in cognitively healthy elderly subjects. The relationship between such changes and cognitive function remains unclear.

Methods

The present study evaluated the relationship between the degree of white matter changes and cognitive function using data from 172 cognitively healthy subjects who underwent MRI and a battery of neuropsychological tests. The degree of WMHs was rated using a four‐point scale for images on a computer screen.

Results

Regarding the frontal and parieto‐occipital regions and basal ganglia region, compared with the group with no WMHs, the group with the most severe WMHs showed significantly lower performances for attention and disorientation to time, respectively.

Conclusions

Our results suggest that even in cognitively healthy elderly individuals, presence of large WMHs affects performance on certain cognitive domains according to their localization. Copyright Β© 2009 John Wiley & Sons, Ltd.

πŸ“œ SIMILAR VOLUMES

Relationship between white matter T2 hyp
Relationship between white matter T2 hyperintensity and cortical volume changes on magnetic resonance imaging in healthy elders
✍ Miho Ota; Kiyotaka Nemoto; Noriko Sato; Katsutoshi Mizukami; Fumio Yamashita; Ta πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 555 KB

## Abstract ## Objective T2 white matter hyperintensity (WMH) on magnetic resonance imaging (MRI) is associated with brain atrophy. Some previous studies examined the relation between the WMH and cortical atrophy, however, little is known about how the WMHs affect the pattern of cortical atrophy.