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Relationship between viral neurotropism and oncolysis. I. Study of vaccinia virus

✍ Scribed by William A. Cassel; R. Earl Garrett

Publisher
John Wiley and Sons
Year
1967
Tongue
English
Weight
610 KB
Volume
20
Category
Article
ISSN
0008-543X

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✦ Synopsis

Several strains of vaccinia virus were examined in a study of the relationship of viral oncolysis to viral neurotropism. Various animal hosts were challenged intracerebrally with the L strain of vaccinia virus but the virus multiplied only in the brain of one-day-old mice. After 238 passages in mouse brain the virus finally acquired the ability to multiply in the Ehrlich ascites tumor of the mouse and to cause oncolysis. The NEL and LEV vaccinia virus strains initially showed a moderate degree of neurotropism but did not become oncolytic until they were fully adapted to nervous tissue. These results support the concept of a distinct correlation between viral neurotropism and oncolysis and suggest an undetermined similarity between neoplastic and nervous tissues. The findings are significant in considering the application of viruses to human cancers. NCOLYTIC VIRUSES HAVE BEEN A SUBJECT OF 0 interest for many years and a number of review articles cover their b a ~k g r o u n d . ~~ 15, 2O

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