Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease
β Scribed by Snell, Russell G.; MacMillan, John C.; Cheadle, Jeremy P.; Fenton, Iain; Lazarou, Lazarus P.; Davies, Peter; MacDonald, Marcy E.; Gusella, James F.; Harper, Peter S.; Shaw, Duncan J.
- Book ID
- 109916649
- Publisher
- Nature Publishing Group
- Year
- 1993
- Tongue
- English
- Weight
- 431 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1061-4036
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Huntington's disease (HD) is a neurodegenerative and hereditary disease characterized by progressive movement disorders and mental and behavioral abnormalities. The HD gene is an expanding and unstable trinucleotide repeat (CAG repeat sequences). We studied 77 individuals from 38 families with HD in
## Abstract The objective of this study was to examine the relationship between CAG repeat length (CAGn) and clinical progression in patients with Huntington's disease (HD). There are conflicting reports about the relationship between CAGn and clinical progression of HD. We conducted an analysis of