Relationship between total body clearance of caffeine and urine flow rate in elderly men
✍ Scribed by John M. Trang; James Blanchard; Kenneth A. Conrad; Gail G. Harrison
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 277 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0142-2782
No coin nor oath required. For personal study only.
✦ Synopsis
The total body clearance (CL), renal clearance (CL,), and nonrenal clearance (CL,,) of caffeine from plasma were determined following the intravenous administration of caffeine (4mgkg-') to ten healthy men (aged 6686 years) on three separate occasions. Positive correlations were observed between CL and urine flow rate (UFR), between CLR and UFR, and between CLN, and UFR (r = 0.8947, p = 0-0002; r = 0.8832, p = 0.0003; and r = 0.8920, p = 0.0002, respectively). Previous studies have established similar relationships between CL, and UFR for caffeine and its initial dimethylxanthine metabolites; theophylline, theobromine, and paraxanthine. A relationship between CL and UFR has not been reported previously.