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Relationship between the Recovery from Sublethal X-Ray Damage and the Rejoining of Chromosome Breaks in Normal Human Fibroblasts

✍ Scribed by Joel S. Bedford and Michael N. Cornforth


Book ID
124656506
Publisher
Bioone
Year
1987
Tongue
English
Weight
595 KB
Volume
111
Category
Article
ISSN
0033-7587

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## Abstract Wortmannin (WM) is a potent inhibitor of the catalytic sub‐unit of DNA‐PK, which is involved in one pathway of DNA double‐strand break (DSB) rejoining, and of ATM, which functions upstream in the p53 signaling pathway. WM is known to be an efficient radiosensitizer in a variety of mamma