Relationship between the increase of secretion of sTNFα induced by lipopolysaccharides and the enhanced expression of TACE mRNA in HL-60 cells and adhesive cells from human spleen

Inhibition of the arachidonic acid pathw

Inhibition of the arachidonic acid pathway prevents induction of IL-8 mRNA by phorbol ester and changes the release of IL-8 from HL 60 cells: Differential inhibition of induced expression of IL-8, TNF-α, IL-1α, and IL-1β

✍ R. W. Meier; G. Niklaus; B. Dewald; M. F. Fey; A. Tobler 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 1004 KB

The promyelocytic HL 60 cell line can be used as an in vitro model system to study hematopoetic cell differentiation and inflammatory events. We studied the signal transduction pathway of induced interleukin (IL)-8 expression and compared it with those of tumor necrosis factor alpha (TNF-a), IL-l a,