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Relationship between the cardiac response to acute intoxication and alcohol-induced subjective effects throughout the blood alcohol concentration curve

✍ Scribed by Caroline Brunelle; Sean P. Barrett; Robert O. Pihl

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 121 KB
Volume: 22
Category: Article
ISSN: 0885-6222
DOI: 10.1002/hup.866

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✦ Synopsis

Abstract

Rationale

There is evidence to suggest that individual differences in the subjective response to alcohol exist and exaggerated cardiac response to alcohol has been suggested to be a marker of increased sensitivity to the stimulant properties of alcohol.

Objectives

The present investigation examines the relationship between cardiac reactivity to alcohol measured on the ascending limb of the Blood Alcohol Concentration (BAC) curve and the subjective stimulant and sedative effects of alcohol throughout the BAC curve.

Methods

The stimulant and sedative effects of alcohol anticipatory to alcohol and during the ascending and descending limbs of the BAC curve were evaluated using the Biphasic Alcohol Effects Scale in 39 male social drinkers.

Results

Cardiac response to ethanol measured on the ascending limb of the BAC curve was positively correlated with intoxicated stimulant effects at numerous time points during the ascending and descending limbs of the BAC curve (__p__s < 0.01). No associations were found between cardiac change following alcohol and alcohol‐related sedative effects at any time point.