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Relationship between tardive dyskinesia,l-Dopa-induced hyperkinesia and parkinsonism

✍ Scribed by Jes Gerlach

Publisher
Springer
Year
1977
Tongue
English
Weight
468 KB
Volume
51
Category
Article
ISSN
0033-3158

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✦ Synopsis

Psycho pharmacology

9 by Springer-Verlag 1977 -Disability stage is estimated from 0 (no parkinsonism) to V (maximally disabled by parkinsonism) (Hoehn and Yahr, 1967). Webster score represents total score according to the rating scale used (Webster, 1968). Bradykinesia, rigidity and tremor are scored from 0 to 3. The L-Dopa hyperkinesias are scored as follows: the oral movements (tongue and mouth) from 0 to 6; head movements from 0 to 3; and upper extremity movements (shoulder, whole arm, elbow, wrist and fingers) from 0 to 15.

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## Abstract Dyskinesia is a frequent and disabling side effect in patients with Parkinson's disease treated with chronic dopatherapy. Preclinical data in the 1‐methyl‐4‐phenyl‐1,2,3,6,‐tetrahydropyridine (MPTP) monkey suggest that alpha‐2 antagonists may reduce dihydroxyphenylalanine (L‐DOPA)‐induc